Introduction
Osteoporosis is a condition that weakens bones, making them fragile and more likely to break. It develops slowly over several years more often in females than in males.
Currently, it has been estimated that more than 200 million people are suffering from Osteoporosis. According to recent statistics from the International Osteoporosis Foundation, worldwide, 1 in 3 women over the age of 50 years and 1 in 5 men will experience osteoporotic fractures in their lifetime.
Often, people with Osteoporosis suffer from the following injuries:
- broken wrist
- broken hip (Fracture)
- broken spinal bones (vertebrae)
However, in people suffering from Osteoporosis fractures can occur in other bones too, such as in the arm or pelvis. Sometimes a cough or sneeze can cause a broken rib or partial collapse of one of the spinal vertebrae etc.
Although a fracture in one of the bones is often the first sign of osteoporosis, some older people develop spinal kypho-scoliosis, the characteristic stooped (bent forward or sideward) posture. It happens when the bones in the spine have broken, making it difficult to support the weight of the body.
Osteoporosis can be treated with bone strengthening medicines. Currently, there are various drugs such as Denosumab, Calcium and hormonal injections, teriparatide etc.
Teriparatide is known for its effectiveness in building bone density and in the bone trabecular reconstruction, two essential elements in the treatment of Osteoporosis. However, its poor bio-availability by oral route makes it ineffective for the treatment of Osteoporosis and given as an injection is not convenient.
NiedlFree’s solution for administration of Teriparatide (NFTP-205) that can be effective and convenient is in the form of either Oral or Nasal spray.